The regulation, assessment, and management of medical devices is increasingly of interest to policy makers and health system experts in Mexico underlined by recent policy change. For instance, one output of policy discussion is the creation of the Federal Commission for the Regulation and Surveillance of Health Care Services and Facilities that is intended to intervene between aspects of regulation and quality of health services. This paper’s objective is to analyse positions of stakeholders to three alternative strategies to improve processes and practices with regard to the regulation, assessment, and management of orthopaedic medical devices ‘OMD’ in Mexico. The study was based on document analysis and semi-structured interviews to conduct a stakeholder analysis aiming at evaluating the political feasibility of three alternative strategies to improve. Overall, many of the participating stakeholders (e.g. government officials, health care facility employees, and medical device industry) had a strong interest in the principles of alternative strategies. We found that governmental bodies concerned with quality, safety, and cost-effectiveness of health services were the most important stakeholders to the discussed strategies. The majority of stakeholders had a positive position to changes of current processes and practices; only few interviewees identified potential contras such as additional costs that changes to current processes and practices would cause. This study provides important insights into the position of different stakeholders regarding changes of current processes and practices. It may contribute to enhancing the policy environment and deliberation between different interest groups that are potentially affected by the discussed strategies, and help to make progress in the areas concerned by this study.